APPLICATION ID 1553

Dolutegravir

COMPOUND IDENTIFICATION

Compound Name Dolutegravir
Dolutegravir

CHROMATOGRAM

Chromatogram

ANALYTICAL REPORT

Column Trade Name

Column Size / Particle Size

CHIRALPAK® IF-3

250 x 4.6mm / 3µm

Mobile Phase Composition

10mM KPF6 aq. pH2.0 / methyl tert-butyl ether / acetonitrile = 40 / 5 / 55

Chromatographic Mode

Reverse Phase

Flow rate (ml/min)

1

Injection amount (mg)

0.01

Temperature (°C)

25

Pressure (MPa)

Detection

UV 260 nm

Elution order

Enantiomer, API

No.

Rt

K’

1

12.28

3.09

2

15.46

4.15

Alpha Value

Resolution

1 - 2

1.34

3.96

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