APPLICATION ID 184

Argatroban (enriched and separated from its (21S)-diastereomer)

COMPOUND IDENTIFICATION

Compound Name Argatroban (enriched and separated from its (21S)-diastereomer)
Argatroban (enriched and separated from its (21S)-diastereomer)

CHROMATOGRAM

Chromatogram

ANALYTICAL REPORT

Column Trade Name

Column Size / Particle Size

CHIRALPAK® IA-3

150 x 4.6mm / 3µm

Mobile Phase Composition

n-hexane / 2-propanol / trifluoroacetic acid / diethylamine = 95 / 5 / 0.4 / 0.3

Chromatographic Mode

Normal Phase
Primary screening solvent (Immobilised CSP)

Flow rate (ml/min)

0.7

Injection amount (mg)

Temperature (°C)

25

Pressure (MPa)

Detection

UV 330 nm

Elution order

No.

Rt

K’

1

9.12

2.55

2

11.14

3.33

Alpha Value

Resolution

1 - 2

1.31

2.63

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