APPLICATION ID 1489

Afatinib

COMPOUND IDENTIFICATION

Compound Name Afatinib
Afatinib

CHROMATOGRAM

Chromatogram

ANALYTICAL REPORT

Column Trade Name

Column Size / Particle Size

CHIRALPAK® IE

250 x 4.6mm / 5µm

Mobile Phase Composition

methanol / methyl tert-butyl ether / diethylamine = 80 / 20 / 0.1

Chromatographic Mode

Normal Phase
Secondary screening solvent (Immobilised CSP)

Flow rate (ml/min)

0.7

Injection amount (mg)

0.01

Temperature (°C)

15

Pressure (MPa)

Detection

UV 340 nm

Elution order

No.

Rt

K’

1

15.2

2.55

2

16.86

2.94

Alpha Value

Resolution

1 - 2

1.15

2.49

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