APPLICATION ID 1490

Aliskiren

COMPOUND IDENTIFICATION

Compound Name Aliskiren
Aliskiren

CHROMATOGRAM

Chromatogram

ANALYTICAL REPORT

Column Trade Name

Column Size / Particle Size

CHIRALPAK® IE-3

250 x 4.6mm / 3µm

Mobile Phase Composition

methyl tert-butyl ether / acetonitrile / 1,4-dioxane / ethylenediamine = 80 / 20 / 1 / 0.05

Chromatographic Mode

Normal Phase
Secondary screening solvent (Immobilised CSP)

Flow rate (ml/min)

1

Injection amount (mg)

0.05

Temperature (°C)

40

Pressure (MPa)

Detection

UV 280 nm

Elution order

RSSS Isomer, API, SRRR Isomer, RRRR Isomer

No.

Rt

K’

1

18.91

5.3

2

21

6

3

25.3

7.43

4

28

8.33

Alpha Value

Resolution

1 - 2

1.13

2

2 - 3

1.24

2.3

3 - 4

1.12

4.13

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