APPLICATION ID 1496

Bortezomib

COMPOUND IDENTIFICATION

Compound Name Bortezomib
Bortezomib

CHROMATOGRAM

Chromatogram

ANALYTICAL REPORT

Column Trade Name

Column Size / Particle Size

CHIRALPAK® AD-3

250 x 4.6mm / 3µm

Mobile Phase Composition

n-heptane / ethanol / 2-propanol / acetic acid = 90 / 5 / 5 / 0.1

Chromatographic Mode

Normal Phase
Coated CSP

Flow rate (ml/min)

1

Injection amount (mg)

0.005

Temperature (°C)

25

Pressure (MPa)

Detection

UV 270 nm

Elution order

API, SS, SR, RR

No.

Rt

K’

1

8.2

1.73

2

9.76

2.26

3

11.34

2.78

4

13.71

3.57

Alpha Value

Resolution

1 - 2

1.3

3.21

2 - 3

1.23

2.73

3 - 4

1.28

3.63

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