APPLICATION ID 400

Nadolol (four isomers)

COMPOUND IDENTIFICATION

Compound Name Nadolol (four isomers)
Nadolol (four isomers)

CHROMATOGRAM

Chromatogram

ANALYTICAL REPORT

Column Trade Name

Column Size / Particle Size

CHIRALPAK® IA

250 x 4.6mm / 5µm

Mobile Phase Composition

n-heptane / ethanol / diethylamine = 85 / 15 / 0.1

Chromatographic Mode

Normal Phase
Primary screening solvent (Immobilised CSP)

Flow rate (ml/min)

1

Injection amount (mg)

0.01

Temperature (°C)

25

Pressure (MPa)

Detection

UV 230 nm

Elution order

No.

Rt

K’

1

10.4

2.5

2

12.1

3

3

16.7

4.6

4

27.2

8.1

Alpha Value

Resolution

1 - 2

1.2

2.7

2 - 3

1.5

6.3

3 - 4

1.7

8.1

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