APPLICATION ID 565

Dorzolamide (racemic)

COMPOUND IDENTIFICATION

Compound Name Dorzolamide (racemic)
Dorzolamide (racemic)

CHROMATOGRAM

Chromatogram

ANALYTICAL REPORT

Column Trade Name

Column Size / Particle Size

CHIRALPAK® AD-3

250 x 4.6mm / 3µm

Mobile Phase Composition

n-hexane / ethanol / diethylamine = 80 / 20 / 0.1

Chromatographic Mode

Normal Phase
Coated CSP

Flow rate (ml/min)

1

Injection amount (mg)

Temperature (°C)

40

Pressure (MPa)

Detection

UV 254 nm

Elution order

No.

Rt

K’

1

11.31

2.77

2

13.83

3.61

3

15.42

4.14

4

16.61

4.54

Alpha Value

Resolution

1 - 2

1.3

4.62

2 - 3

1.15

2.64

3 - 4

1.1

1.91

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