APPLICATION ID 673

Nadolol (four isomers)

COMPOUND IDENTIFICATION

Compound Name Nadolol (four isomers)
Nadolol (four isomers)

CHROMATOGRAM

Chromatogram

ANALYTICAL REPORT

Column Trade Name

Column Size / Particle Size

CHIRALPAK® AD-H

250 x 4.6mm / 5µm

Mobile Phase Composition

n-heptane / ethanol / ethanolamine = 80 / 20 / 0.1

Chromatographic Mode

Normal Phase
Coated CSP

Flow rate (ml/min)

1

Injection amount (mg)

0.01

Temperature (°C)

25

Pressure (MPa)

Detection

UV 230 nm

Elution order

No.

Rt

K’

1

10.6

2.5

2

17.3

4.8

3

21.9

6.3

4

64.7

20.6

Alpha Value

Resolution

1 - 2

1.9

10

2 - 3

1.3

5

3 - 4

3.3

18.4

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