APPLICATION ID 979

Lamivudine (containing the enantiomeric impurity)

COMPOUND IDENTIFICATION

Compound Name Lamivudine (containing the enantiomeric impurity)
Lamivudine (containing the enantiomeric impurity)

CHROMATOGRAM

Chromatogram

ANALYTICAL REPORT

Column Trade Name

Column Size / Particle Size

CHIRALPAK® IC

250 x 4.6mm / 5µm

Mobile Phase Composition

ethanol / 2-propanol / diethylamine = 90 / 10 / 0.1

Chromatographic Mode

Polar Phase

Flow rate (ml/min)

1

Injection amount (mg)

Temperature (°C)

25

Pressure (MPa)

Detection

UV 270 nm

Elution order

No.

Rt

K’

1

8.03

1.68

2

9.14

2.05

Alpha Value

Resolution

1 - 2

1.22

3.03

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